Now accepting Telehealth appointments. Schedule a virtual visit.

Fenofibrate slows Diabetic Retinopathy(DR)

Results indicate that fenofibrate may be an effective option for people with early diabetic retinopathy. Over 4 years, participants taking fenofibrate saw a 27% reduction in the progression of their eye disease compared to those taking the placebo.

Fenofibrate may likely reverse diabetes' effects and reduce inflammation in the retina, as well as improving dyslipidemia and hypertriglyceridemia.  Fenofibrate increases levels of circulating apolipoprotein A-I, an independent protective factor for DR.

ApoM might be a useful biomarker for predicting the progression of diabetic nephropathy, and the ApoM/S1P-S1P1 axis might serve as a novel therapeutic target for preventing the development/progression of diabetic nephropathy.

Fenofibrate is available as Antara, Lipofen, TriCor, Triglide, Trilipix, and generic fenofibrate in the following dosage forms that are taken by mouth. 135 mg once daily, Delayed Release Capsule.

https://www.jwatch.org/na57657/2024/06/27/fenofibrate-slows-progression-diabetic-retinopathy

https://www.medscape.com/viewarticle/trial-fenofibrate-slows-diabetic-retinopathy-progression-2024a1000bm8

Author
Paddy Kalish OD, JD and B.Arch

You Might Also Enjoy...

Syncope

Syncope is a synonym for fainting or passing out. Someone is considered to have syncope if they become unconscious and go limp, then soon recover.

Vertigo and Dizziness

Vertigo and dizziness are common symptoms encountered in clinical practice, often requiring careful evaluation to determine their underlying causes. Visual symptoms often accompany vertigo and dizziness, and understanding that relationship is necessary.

Head Trauma and Parkinson's

Head trauma, particularly repetitive or severe injuries, has been linked to an increased risk of developing Parkinson's disease (PD) and other Neurodegenerative disorders.