Now accepting Telehealth appointments. Schedule a virtual visit.

GLP-1 Receptor Agonists have an Additional Role for Headache Relief

Exenatide, a GLP-1 agonist sold under the brand names Byetta and Bydureon by AstraZeneca (LSE: AZN) as a type 2 diabetes drug, could be useful in another indication, a trial has found.

This study, published in the journal Brain, reports on a Phase II trial of the drug as a potential treatment for severe headaches known as idiopathic intercranial hypertension (IIH).

Central sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to this progression. Microglial glucagon-like peptide-1 receptor (GLP-1R) activation can alleviate pain.  Microglial GLP-1R activation in the TNC may suppress the central sensitization of CM by regulating TNC microglial activation via the PI3K/Akt pathway.

What is idiopathic intracranial hypertension?

Idiopathic intracranial hypertension (IIH) is a disorder related to high pressure in the brain. It causes signs and symptoms of a brain tumor. It's also sometimes called pseudotumor cerebri or benign intracranial hypertension.

The fluid that surrounds the spinal cord and brain is called cerebrospinal fluid or CSF. If too much fluid is made or not enough is re-absorbed, the CSF can build up. This can cause symptoms like those of a brain tumor. 

What causes idiopathic intracranial hypertension?

Specialists do not know why IIH occurs. Obesity is a risk factor. Some medicines have been linked to a higher risk of it. These include common medicines like:

  • Birth control pills

  • Certain antibiotics

  • Chemotherapy medicines

  • Steroids

  • Some acne medicines

If you are suffering from IIH or suspect that you may have it, Please consult a Neurologist ASAP.

https://www.youtube.com/watch?v=gqtcmb_gs_I

Author
Paddy Kalish OD, JD and B.Arch Author and Blogger

You Might Also Enjoy...

Mouth Breathing

Mouth breathing occurs when a person breathes primarily through the mouth rather than the nose, often due to nasal obstruction or other health issues

ALS(Amyotrophic Lateral Sclerosis)

ALS (Amyotrophic Lateral Sclerosis) is a progressive and fatal neurodegenerative disease affecting nerve cells in the brain and spinal cord that control voluntary muscles, leading to muscle weakness, paralysis, and ultimately respiratory failure.

Common Hormones and Their Nicknames

Many hormones also have scientific abbreviations and are grouped by chemical classes (e.g., peptide, steroid, amine). The nicknames often come from their most prominent and publicized effects on health or behavior.

A1C

A1C, also known as hemoglobin A1C or HbA1c, is a blood test that measures the average level of blood glucose (sugar) over the past two to three months.

Joint hypermobility syndrome(JHS)

Joint hypermobility syndrome is when one has very flexible joints because the joints are loose and stretchy when the ligaments that should make them stronger and support them are weak

Sjögren's disease i

Sjögren's disease is a chronic autoimmune disorder that mainly affects the glands that produce moisture in the body, such as those responsible for saliva and tears, resulting in symptoms like dry mouth and dry eyes