Head Trauma and Parkinson's
Head trauma, particularly repetitive or severe injuries, has been linked to an increased risk of developing Parkinson's disease (PD) and other Neurodegenerative disorders.
INFLAMMATORY RESPONSE
THE INFLAMMATORY RESPONSE is an immediate, protective pathological process of vascularized tissue to infection, irritation or injury•Heat: increased vascular perfusion delivers core blood to the affected region to facilitate optimal temperatures for enzymatic activity•Redness: local vasodilation facilitates swelling and immune cell infiltration to facilitate destruction or isolation of the pathogen and remove cell debris •Swelling: exudation of plasma and proteins from locally dilated capillaries isolates the wound and pathogen and facilitates immune cell access•Pain: physical swelling and released mediators from immune cells stimulate pain fibers•Loss of Function: local pain reduces mobility of the affected body area which limits movements that could aggravate preparative steps in tissue repair. Tissue repair is a post inflammatory process.
ANTI-INFLAMMATORY THERAPY•Successful therapy coincides with the elimination of the 5 cardinal signs/symptoms of inflammation• Inflammation is a response to a variety of insults:•Radiation toxicity•Mechanical trauma•Chemical toxicity•Infection•Pronounced or exaggerated immune response( Steroids are not curative in this regard)
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